ポピュラーベクター Mouse Gapdh

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014] Annotation information: Note: GeneID 14433 was annotated on chromosome 6 on NCBI\'s Build 36.1 and GeneID 407972 (then associated with the functional Gapdh) was not annotated. Sequences associated with GeneID 14433 also align to chromosome 2 A3, the location of a highly related Gapdh pseudogene that was not annotated on Build 36.1. To connect the nomenclature with the annotation, GeneID 14433 was merged with GeneID 407972 and it now represents the functional Gapdh gene on chromosome 6. The RefSeq for Gapdh is NM_008084 with NM_001001303.1 being secondary to it. The Gapdh pseudogene on chromosome 2 is now represented by GeneID 100033452 and the RefSeq NG_005903.1. [13 Feb 2013]

NM_001289726.2; NM_001411840.1; NM_001411841.1; NM_001411842.1; NM_001411843.1; NM_001411844.1; NM_001411845.1; NM_008084.4

NP_001276655.1; NP_001398769.1; NP_001398770.1; NP_001398771.1; NP_001398772.1; NP_001398773.1; NP_001398774.1; NP_032110.1